Part, Category. Description, 4-bit Shift Register. Company, ETC. Datasheet, Download datasheet. Quote. Find where to buy. Quote. # Store at. °C. 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb . as recommended in the antibody product datasheet) in 10 ml primary antibody. Datasheet PDF Download – 4-Bit Shift Register, data sheet.
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Furthermore, there is an inverse correlation between levels of 5-hmC and histone H3K9 and H3K27 trimethylation, suggesting a role for 5-hmC in gene activation Login Create new account. The supporting documents available for this product can be downloaded below.
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Additionally, TET proteins can further oxidize 5-hmC to form 5-formylcytosine 5-fC and 5-carboxylcytosine 5-caCboth of which are excised by thymine-DNA glycosylase TDGeffectively linking cytosine oxidation to the base excision repair pathway and supporting active cytosine demethylation 6,7.
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As shown in the graph, the antibody only binds to the oligo containing 5-fC. No need to login to view prices! Our website shows product prices without login! You will receive dqtasheet e-mail containing a link to start the recovery procedure within minutes.
Please change your password to something memorable and secure upon logging in. Since then this modification has been discovered in many tissues, with the highest levels found in the brain 9. Many cells and tissues contain very low endogenous levels of 5-fC that may fall below the detection limits of this antibody.
This product is intended for research purposes only. The upper panel shows the antibody only binding to the DNA fragment containing 5-fC, while the lower panel shows the membrane stained with methylene blue. TET protein-mediated cytosine hydroxymethylation was initially demonstrated in mouse brain and embryonic stem cells 5, 8. Therefore webshop accounts that were only used to view prices have been deleted.
Lower amounts of 5-hmC have been reported in various cancers including myeloid leukemia and melanoma 13, The product is not intended to be used for therapeutic or diagnostic datawheet in humans or animals. Contact us and we will help you. The same sequence of a base pair DNA fragment was generated datasneet PCR using exclusively unmodified cytosine, 5-methylcytosine 5-mC5-hydroxymethylcytosine 5-hmC5-carboxylcytosine 5-caCor 5-formylcytosine 5-fC.
Application References Have you published research involving the use of our products? Background Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2.
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Please refer to this page. The modified base itself is stable in vivo and interacts with various readers including MeCP2 11, Have you published research involving the use of our products? Please let us know! Have trouble resetting your password? Methylation of Datasheett at cytosine residues is a heritable, dataaheet modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2.
Datashwet 5-fC and 5-caC appear to be short-lived intermediate datsaheet, there is mounting evidence showing that 5-hmC is a distinct epigenetic mark with various unique functions 10, The global level of 5-hmC increases during brain development, and 5-hmC is enriched at promoter regions and poised enhancers. The antibody was titrated against a single-stranded DNA oligo containing either unmodified cytosine or differentially modified cytosine 5-mC, 5-hmC, 5-caC, 5-fC. Your credentials are incorrect or you are trying to login with a non-existing webshop account.
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