September 27, 2020

The formulation containing HPMC K15MCR and Polyox WSR at the Sorry, there is no online preview for this file type. Ranitidine can be found in many pharmaceutical firms such as tablets, injectable solutions and oral Dissolution enhancement of aceclofenac tablet by solid dispersion technique. short biological half life demands continuous intravenous infusion or time spaced injection. We chose tristearin as solid lipid and formulated it in nanoparticulate form by an ultrasonic Sorry, there is no online preview for this file type. Enhanced skin delivery of aceclofenac via hydrogel-based solid lipid nanoparticles. Injectable. Moderate. REACTION TO SEPTRIN PROPHYLAXIS IN A NEWLY STARTED SWEATING WITH CHANGE IN HAEMODYNAMIC STABILITY. 1. 1 Injectable. Mild. 2. ORAL DICLOFENAC 50MG, HAEMOPTYSIS.

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According to its another embodiment, the present invention provides a process for preparing a nonaqueous liquid parenteral Aceclofenac formulation for pharmaceutical application, which process comprises of the steps of. Any NSAID which, therefore, has comparable or better gastrointestinal tolerability than these two drugs is likely to be well accepted for long-term therapy of RA.

Hence in view of the above discussions there is a perceived need for development of Aceclofenac in stable injection form and a method of preparing the same injection and also a method of treating a subject having a condition or disorder wherein a very urgent treatment with a NSAID is indicated, this very urgent treatment being given by administering Aceclofenac in an injection form.

The Aceclofenac formulation of any of Items 1 and 5 wherein said nonaqueous solubilizer component is selected from the group consisting of propylene glycol and optional ethanol. Although any methods and materials similar or equivalent to those described herein can also be used in the practice or testing of the present invention, the preferred methods and materials are now described. The Aceclofenac formulation of Item 19, wherein said Aceclofenac salt is present in an amount corresponding to single unit dose, wherein said sealed airtight container of any of Items 20 and 21 is preferably a glass ampoule.


Thus, this study opens the chance of preparing aqueous formulations of poorly-water soluble drugs, if chemical stability of the drug remains unaffected.

USA1 – Nonaqueous liquid parenteral aceclofenac formulation – Google Patents

II Physical stability study of formulated lyophilized injection of aceclofenac. List of Inactive Ingredients used by the innovator Formulattion qualitatively Q1 and quantitative levels of excipients Guidance on proposed formulation and its labeling tormulation. Such compositions are useful in treatment of pain and inflammation caused by asthma, bronchitis, menstrual cramps, preterm labor, tendonitis, bursitis, allergic neuritis, cytomegalovirus infection, apoptosis including HIV-induced apoptosis, lumbago, skin-related conditions such as psoriasis, eczema, acne, burns, dermatitis and ultraviolet radiation damage including sunburn, and post-operative inflammation including that following ophthalmic surgery such as cataract surgery or refractive surgery.

US DMF type requires module 3 and admin information.

Rajkumar Gupta – Google+

The stable injectable pharmaceutical compositibn of aceclofenac may, be prepared as given in table 1. Pharmaceutical compositions containing pemetrexed having extended storage fildtype. During the performance of clarity test on the reconstituted lyophilized injection formulation, no black or white particles were seen. Laminating various films one above the other using heat and adhesives five to eleven layers 2.

An object of the present invention is to provide Aceclofenac in ready-to-use injection form.

US20090156670A1 – Nonaqueous liquid parenteral aceclofenac formulation – Google Patents

Parenteral routes of administration, including subcutaneous, intramuscular and formulatin injection, offer numerous benefits over oral delivery in particular situations, for a wide variety of drugs. Thus, the same solution can be used for lyophilization within 4 h and 12 h, respectively, under unavoidable conditions. The Aceclofenac formulation alternatively comprises additional one or more salicylic acid derivative s and nonaqueous solubilizer components, the additional nonaqueous stabilizer components being substantially inert.

The Aceclofenac formulation of Item 19 wherein said Aceclofenac salt is present in an amount corresponding to fornulation of single 1 to 20 unit doses. Synergistic combination of hydrotropic agents can minimize the amount of hydrotropic agents employed, minimizing the chances of their toxicities.

Other object of the present invention is to provide a formulation which is convenient to use and stable for much longer time as compared to dry powder aceclofenac injection. Aceclofenac component in a form of non-water-soluble Aceclofenac salt. The solvent system was allowed to run for a height of about 4 cm. The required formu,ation of dosage is provided in a sealed airtight container which is selected from the group consisting of a vial, and ampoule, knjection syringe, a packet, a pouch and an auto-injector.


Prior art also discloses pharmaceutical composition of an aqueous solution of arginine and ibuprofen comprising a molar ratio of arginine to ibuprofen, which is less than 1: However, the term has been used in the literature to designate non-micelle-forming substances, either filehype or solids, organic or inorganic, capable of solubilizing insoluble compounds.

However, there was no increase in weight of the control sample, which indicates that the sample when kept under controlled conditions, is safe and there is no moisture uptake.

Additionally a formulation of aceclofenac with arginine would give rise to a formulation with formuulation pH in which the aceclofenac would be instable unlike ibuprofen which is stable at alkaline pH.

Before the present process and methods are described, it is to be understood that this invention is not limited to particular compounds, formulas or steps described, as such may, of course, vary. Furthermore, results of previous comparative clinical trials with ketoprofen showed that aceclofenac, while being similar in terms of therapeutic efficacy, demonstrates a better safety and tolerability profile.

Mixed hydrotropic solubilization technique is the phenomenon to increase the solubility of poorly water-soluble drugs, using blends of hydrotropic agents A process as in claim 3, wherein the stable injectable pharmaceutical composition comprising an aqueous solution of arginine and aceclofenac in the molar ratio of arginine to aceclofenac in the range of about 1. Tang X, Pikal MX. Hydrotropic solubilization process involves cooperative intermolecular interaction with several balancing molecular forces, rather than either a specific complexation event or a process dominated by a medium effect, such as co-solvency or salting-in.

Alternatively, the amount of the Aceclofenac salt in the sealed airtight container is corresponding to 1 to 20 unit doses. Initial treatment can begin with a dose regimen as indicated herein.

At a pH of less thari;6.