Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.
|Published (Last):||28 September 2017|
|PDF File Size:||1.81 Mb|
|ePub File Size:||12.1 Mb|
|Price:||Free* [*Free Regsitration Required]|
Ann Otol Rhinol Laryngol. Data concerning survival recurrence and metastasis were evaluated. Mucoepidemroide effects of age, gender, anatomic localization, tumor size, clinical stage, histological grade, recurrence, metastasis, compromised surgical margins and treatment on clinicopathological outcomes were investigated. The three-level grading system commonly used by pathologists for MEC classification mainly considers the relative proportion of cell types epidermoid, intermediate and mucinous cellstheir respective degrees of atypia and growth patterns cystic, solid, or infiltrativetogether with neural and vascular invasion.
Further studies in order to clarify this point are warranted. The 5 and year overall survival rates were both Mucoepidermoid carcinoma MEC is the most vlandulas malignant neoplasm of major and minor salivary glands Lopes et al, R; Dempsey, R J.
Thus, the aim of this study was to analyze a series of intraoral MEC for expression of the c-erbB-2 oncoprotein and its possible association with the clinicopathologic features of the sample.
The mucoepidermoid carcinoma generally shows an extremely aggressive pattern for high-grade tumors, whereas its respectivee low-grade counterpart is often indolent and slow-growing. In contrast to results reported by Nance and others 4 in present study was not observed any association between positive surgical margins and decreased DFS. Inmunostaining for ki67 were made. The biological features and clinical behavior of mucoepidermoid carcinomas are widely variable and poorly understood.
Through a long follow-up period in present study we could highlight the relevance mucoeppidermoide primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head carcihoma neck mucoeoidermoide carcinomas. MEC is reported to manifest variable biologic aggressiveness, basically showing correlation with its histological features and is graded by a 3-tiered system Auclair et al, However, there are few articles with a significative number of cases Lopes et al.
Although this current investigation mucoepirermoide limited by a relatively small sample size, there was a long follow-up period in which we could verify and confirm the influence of some prognostic factors.
The high percentage of previously observed positive cases 21 cases, This study aimed to investigate prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas. The tumoral histological grade was associated with the ki67 expression, relevant prognosis factors in MEC.
Due to the singularity and diverse histology of these tumors, prognostic factors have been difficult to elucidate. Although the significance of this cytoplasmic staining remains unknown, Cheng et al. Previous studies of c-erbB-2 expression in salivary gland carcinomas are sparse, comprise heterogeneous subtypes, and show contradictory results Locati et al. Clinical information about age, gender, and site were obtained from the biopsy records.
The parotid was the most affected gland, followed by the palate and sub maxillary, which agree with the bibliography. Casilla D Temuco – Chile Tel.: MEC is composed of varying proportions of mucous, epidermoid, columnar, intermediate and clear cells Auclair et al. MEC is the most common malignancy of salivary glands and presents a diverse age distribution Auclair et al; Lopes et al. The disease-free interval for recurrences and metastases ranged from 22 to months and 22 to months, respectively.
Casilla D Temuco – Chile Tel.: From oral biopsies submitted during period between and ,40 0. Moreover, Gibbons et al.
The medical and surgical records of all cases were reviewed for clinicopathological factors, such as age, gender, primary tumor location, tumor size, clinical stage, histological grade, treatment, compromised surgical margins, tumor recurrence, metastasis, disease-free survival DFS and overall survival OS.
Jpn J Clin Oncol.
Carcinoma of the parotid and submandibular glands a study of survival in patients. It is composed of mucous, epidermoid, intermediate, columnar and clear cells. Am J Surg Pathol. Studies on intra-oral MEC have shown similar results with a higher percentage of low grade tumors Kokemueller et al.
Blocking of endogenous avidin-botin activity in immunohistochemistry.
The c-erbB-2 oncoprotein is involved in matrix degradation and proteolitic activity as well salivalees in the increase in vessel permeability, endothelial cell growth, proliferation, migration, and differentiation Verbeek et al. Published works usually lose relevant survival information through time.
In situ intraductal carcinoma of the breast was used as a c-erbB-2 positive control and negative controls were obtained by the omission of the primary antibody. Thus, our findings may suggest the lack of association among clinicopathological features and the saliva,es of c-erbB Sinonasal and maxillary tumors were not included in this study as intraoral salivary gland tumors since that in these locations mucoepidermoid carcinoma presents different origin rather than glandular Ellis et al.
Survival curves were generated using the Kaplan-Meier method and analyses were performed using the log rank test. However, in the study of Lopes et al. Considering the results in the appraised sample, our findings suggest that some mucoepidermoid carcinoma overexpress c-erbB-2 independent of mkcoepidermoide features such as patient age and gender and site or histological grades of the lesions.
MEC than that from intercalated duct. Its intracellular component has a tyrosine kinase activity, carcinoja the extracellular domain may act as a growth factor receptor because of its considerable homology with epidemial growth factor receptor Nguyen et al. Histological and Inmunohistochemical Prognostic Factors. Discrepancies were solved by consensus. Salivary glands ; ucoepidermoid carcinoma ; Prognostic factors.