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Review Article necessary and various intracanal medicaments have been tried. Intracanal medicaments, calcium hydroxide, antibiotics, corticosteroids. free root canal systems, especially in pulpless teeth, it is necessary to use intra- canal medicaments. These medicaments must be capable of destroying bacteria . Request PDF on ResearchGate | Antibiotics as intracanal medicaments: a review | Antibiotics are an extremely valuable addition to the armamentarium.

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Author information Article notes Copyright and License information Disclaimer. A clinical question that supports the decision about the antibacterial efficacy of intracanal medicaments on bacterial biofilm cannot be answered using a critical longitudinal analysis of published articles. Relevant clinical considerations are yet to be elucidated, such as the efficacy of intracanal medicament on bacterial biofilm, the time necessary for a mature endodontic biofilm to form or the ideal biofilm model to assess antimicrobial endodontic substances.

However, innumerous published articles on endodontic infection control are motive of controversy 19 – 111619242635 The role of environmental changes on monospecies biofilm formation on root canal wall by Enterococcus faecalis. Surface adherence by bacteria to form biofilms is a good example of bacterial adaptation. The variations observed in these clinical isolates suggested that biofilm formation might be an important factor when considering the virulence phenotype of endodontic strains in general.

From a total of 91 articles, 8. However, the results of this critical review confirmed that root canal preparation, with rfview disinfection and use of intracanal substances that provide good antimicrobial efficacy, tissue dissolution capacity, and acceptable biocompatibility, will definitely improve the prognosis of the treatment of apical periodontitis 25 Based on the inclusion and exclusion, 91 articles were selected, of which 17 Intrafanal and Kishen 14 Yag laser irradiation of the microbiological apical biofilm.

Duggan and Sedgley 10 tested the hypothesis that the ability of E. Evidence-based dentistry involving systematic reviews or meta-analyses has intdacanal the ultimate goal to integrate the best available research evidence with clinical experience.

Interestingly, a recently published study contemplating the clinical aspects about the bacterial biofilm is the only one with high level of evidence.


Antibiotics as intracanal medicaments: a review.

Open in a separate window. Identification and localization of extraradicular biofilm-forming medicamebts associated with refractory endodontic pathogens. The microenvironment of root canal presents excellent conditions to establish microbial growth Handsearching was conducted by the review of the reference lists of the eligible clinical trials and the review of author’s personal databases of trial reports in an attempt to identify any other relevant studies.

Susceptibility of oral bacterial biofilms to antimicrobial Agents. In vitro studies Studies performed in animals Studies related only to microbial identification Studies not related to the efficacy of intracanal medicaments on endodontic biofilm Studies related to mediacments periapical biofilm Studies related to the non-endodontic biofilm Studies only with abstract or with no available abstract Literature reviews Case reports.

Comparative evaluation of antimicrobial efficacy of sodium hypochlorite, MTAD, and Tetraclean against Enterococcus faecalis biofilm. Coronal leakage of mixed anaerobic bacteria after obturation and post space preparation.

Relevant aspects of the studies that met the inclusion criteria were considered, such as the experimental model and sample size, the time lapsed from the initial endodontic treatment until the present moment, the method of identification of the bacteria, the presence of bacteria on the initial samples, the chemical substances used during the root canal disinfection, the time of maintenance of the intracanal dressing prior to obturation, and the efficacy of the medicaments against the tested bacteria.

None of the 8 articles referring to in vivo mesicaments met all inclusion criteria Table 3. Abstract The purpose of this paper is to discuss critically the antibacterial efficacy of intracanal medicaments on bacterial biofilm.


The search retrieved 91 related articles, of which 8. Longitudinal studies signalize that there is yet no accurate solution to eliminate or disrupt the root canal bacterial biofilm.

Disagreements were resolved by consensus. In vitro antimicrobial activity of sodium hypochlorite and chlorhexidine against selected single-species biofilms. Photodynamic therapy for endodontic disinfection. Photophysical, photochemical, and photobiological characterization of methylene blue formulations for light-activated root canal disinfection.


This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Toxicity testing of dental materials. Socransky and Haffajee 37 reported that the reason for the itracanal of a biofilm is that it allows microorganisms to stick to and multiply on surfaces.

Inclusion criteria In vivo studies, in humans.

J Appl Oral Sci. The assessment of systematic reviews in dentistry. Study Selection The selected articles were identified from titles, abstracts and full-text articles by two independent reviewers, considering the tabulated inclusion and exclusion criteria. Participation of bacterial biofilms in refractory and chronic periapical periodontitis. Resistance can result from restricted inhibitor penetration, slower bacterial growth rates, transfer of resistance genes, suboptimal environmental conditions for inhibitor activity, and the expression of a resistant phenotype Autoaggregation and coaggregation of bacteria associated with acute endodontic infections.

The major difficulty found in the present study was the great deal of available information, and the large number of investigations with agreeing and disagreeing conclusions.

In accordance with this study, other investigations also recovered microorganisms from teeth with endodontic infection after antimicrobial endodontic therapy 6 Biofilms in endodontic infections. Law A, Messer H.

kedicaments The findings of in vitro studies Table 4 show an antimicrobial effectiveness of intracanal medicaments on bacterial biofilm 139 similarly to in vivo evaluations involving the presence of biofilm on all external root apex surfaces in teeth with pulp necrosis with periapical lesions In order to develop new treatments to eradicate E.

Response to alkaline stress by root canal bacteria in biofilms. The susceptibility of oral bacterial biofilm to antimicrobial agents indicates the medidaments to reproduce in vivo conditions where bacteria grow as biofilm on tooth surfaces