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Human beta-interferon gene expression is regulated by an inducible enhancer element. Images in this article Image on p.
Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor. National Center 4160 Biotechnology InformationU. Controlled transcription of a human alpha-interferon gene introduced into mouse L cells.
The 5′-flanking sequence of human interferon-beta 1 gene is responsible for viral induction of transcription. The human beta-interferon gene enhancer is under negative control. Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase. Biochemistry of interferons and their actions.
Irr data suggest that IRF-1 participates in the transient formation of an induction-specific complex es with the regulatory elements. Interaction of positive and negative regulatory proteins in the galactose regulon of yeast.
Delimitation and properties of DNA sequences required for the regulated expression of human interferon-beta gene. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.
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Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Author information Copyright and License information Disclaimer. Changes of chromatin conformation around mouse interferon-beta gene associated with induction of interferon synthesis.
Establishment of a permanent cell line HEL-R66 from human embryonic 410 cells with high susceptibility to viruses. In this study, we describe a nuclear factor, termed interferon regulatory factor-1 IRF-1that is involved in the transcription of IFN-beta and possibly other genes.
A rapid and sensitive assay system for bacterial gpt activity in transfected mammalian cells. A nucleotide promoter segment from an IFN-alpha gene renders an unrelated krf inducible by virus. Abstract Transcription of the human interferon-beta IFN-beta gene is induced by a variety of agents such as viruses, dsRNA and some cytokines.
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Sequencing end-labeled DNA with base-specific chemical cleavages. Regulation of cytokine gene expression. BK viral enhancer element and a human cellular homolog. High efficiency DNA-mediated transformation of primate cells. Associated Data Supplementary Materials.
Open in a separate window. This article has been cited by other articles in PMC. Heat shock factor is regulated differently in yeast and HeLa cells.
Affinity purification of sequence-specific DNA binding proteins.